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Feb 08

Emerging Ideas In Speedy Strategies In Urology

A team at the University of Liverpool, in collaboration with Public Health England, Boston University Shared this and other international partners, used blood samples taken from infected and recovering patients during the 2013-2016 West Africa outbreak to identify gene products that act as strong predictors of patient http://josiahalexanderfun.khmermerchant.com/2017/01/29/the-first-thing-to-do-is-address-the-issue-of-cravings-and-not-through-some-artificial-appetite-suppressant outcome. Funded by the National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections and the United States Food and Drug Administration, the new research provides data on the underlying causes of Ebola virus infection and suggests that this type of blood analysis could be integrated into future outbreak responses as a diagnostic tool to help guide treatment strategies. Since the Ebola outbreak in West Africa much research has been done to further understand the biology of the Ebola virus. In particular, the processes that lead to survival or a fatal infection are unknown, although the amount of virus present in the body (viral load) can be a key determinant. However, while this premise worked well for predicting outcomes for people with extreme viral loads, it was less clear for people with mid-range counts, the majority of cases, where the outcome prediction was approximately equal between survival and a fatal infection. The results of this new study, which are published in Genome Biology, identified a small number of genes whose expression accurately predicts patient survival, independent of viral load. Blood samples collected by the European Mobile Laboratory in Guinea of Ebola patients who either went on to survive or die from the acute infection, were analysed using genomic techniques to identify and quantify messenger RNA (mRNA) expression. These results were compared to blood samples from a separate group of survivors who had recovered from infection and were now free of the Ebola virus. The analysis also provided some fundamental information on the host response to Ebola virus infection in humans, and found that an immediate robust immune response didn’t affect whether people went on to live or die from the infection. The data also points to the virus causing significant liver damage.

For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2017-01/uol-btc011817.php

UK medicine

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